Study results: These 3 active ingredients make a difference!
In an in vivo clinical study by the company “Sederma”, women and men with hair loss tested the effects of Procapil™ for 4 months. The men applied a conditioner containing the active ingredient to their hair twice a day, and the women applied it twice a day at least every other day.
Hair samples were taken from the participants and they also assessed their own hair loss circumstances themselves. The same research and interviews were done with a placebo group using a routine without Procapil.
Study results: self-assessment
After 4 months , participants made the following comments:
Examination of the hair samples
After 4 months , the following was found on the hair:
Comparative study with minoxidil
Minoxidil is one of the most proven hair loss and hair growth remedies. For the direct comparison of Procapil™ with Minoxidil, incubated hair follicles were treated with Procapil™ or Minoxidil at a concentration of 2 ppm for 2 weeks and examined.
Incubated hair follicles without the addition of an active ingredient were used as a control group.
It turned out that Procapil™ is just as effective as Minoxidil at exactly the same concentration. With a higher concentration of 4 ppm with Procapil™ the effect is intensified.
The figures show the comparison between the control group (top left), the hair follicle treated with Minoxidil (red) and the hair follicle treated with Procapil™ (blue) in 2 different concentrations.
The Swiss Mibelle Biochemistry Group examined the effect of AnaGain™ on women and men with mild to moderate hair loss between the ages of 21 and 37. In the crown area, an area of 0.7 cm² was shaved short and photographed after 2 days. The hair that grew in the 2 days could be assigned to the growth phase (anagen) and all the remaining hair to the resting phase (telogen) in which the hair falls out.
Participants applied AnaGain™ twice a day for 3 months. The results were evaluated once based on the hair coverage in the crown area and once as a self-assessment of the subjects.
In another study, hair bulbs were plucked from men and examined using PCR. These were analysed once without the application of any drug and once after the participants had applied a gel with AnaGain™ for 2 weeks.
Study Results: Examination of the hair bulbs
After 2 weeks the following was found:
Observation of the vertex area
After 3 months, the following was noted on the hair:
- 28% less hair in the resting phase
- 10% more hair in the growth phase
- The result is increased hair density
Good to know:
The designation A/T indicates the relationship between anagen hair (growth phase) and telogen hair (resting/loss phase). If this factor is over 5, the hair loss is normal. In the study participants with mild to moderate hair loss, AnaGain™ improved this factor from 4 to 7.2.
After 3 months, participants made the following comments:
The Mibelle Biochemistry Group from Switzerland conducted a clinical study in which isolated human hair follicles were enriched with 0.2% plant stem cells and examined for 20 days. For comparison, isolated human hair follicles without the addition of the extract were observed for the same time.
Only hair follicles that are in the growth phase were selected.
At this point it was already observed that isolated hair follicles expand in this phase up to the 14th day. Then they usually succumb to cell death, since they cannot be kept alive for a long period of time due to the lack of blood circulation.
As expected, the hair follicles started growing without the addition of the stem cell extract to shrink after day 14. Those hair follicles that contain the stem cells however, prolonged their lifespan to day 18.
As expected, without the addition of the stem cell extract, the hair follicles began to shrink after day 14. However, those hair follicles treated with the stem cells extended their lifespan to day 18. Vitality maintenance was improved by 92%, which means that the hair follicles live almost twice as long without nutrient supply even in isolation from plant stem cells than without.
This resulted in the following findings about the effect of plant stem cells on non-isolated hair follicles:
Extension of the growth phase of the hair
Delaying hair follicle ageing
The overall picture results in a higher hair density